ABSTRACT
This research was conducted to study the follicular dynamics, hormonal, biochemical profile and fertility response in acyclic and norgestomet+PMSG treated acyclic buffaloes in summer. The study animals were divided into two groups: group I [control [n=8]: no treatment] and II [treatment group [n=15]]. In group II, seven animals were used for follicular biochemical and hormonal profile and eight animals for fertility studies following Crestar[registered sign] [Intervet, France] treatment [day 0: Crestar[registered sign] insertion; day 8: 500 IU PMSG; day 9: Crestar[registered sign] removal; day 11 AI]. Follicular fluid stradiol [E2] and progesterone [P4] in acyclic and pre-ovulatory follicle in study groups was significantly [P<0.01] higher than peripheral level. Peripheral E2 concentration, during pre-ovulatory period in group II was higher [P<0.05] than group I. Significant correlation between serum and follicular E2 was deduced [r=0.888; P<0.01] as significant difference in serum cholesterol content was shown between groups. Lower follicular total protein [P<0.05] in acyclic animals and higher follicular glucose [P<0.05] in treated group were concluded. Significant correlation [r=-0.770; P<0.05] was observed between follicular cholesterol and triglycerides. Follicular characteristics, post PMSG administration, differed significantly [0.83 +/- 0.20 vs 1.32 +/- 0.12; P<0.01] in all buffaloes exhibiting estrus, out of which four conceived. In conclusion, follicular hormonal and biochemical profile exhibits alteration in protein and glucose level between summer acyclic and treated buffaloes. However, peripheral E2 along with fertility response showed significant difference [P<0.01] between the study groups with significant correlation in E2, cholesterol and triglycerides between peripheral and follicular compartment
ABSTRACT
The present work aimed at studying growth pattern and carcass traits in pearl grey guinea fowl fed on dietary Neem [Azadirachta indica] leaf powder [NLP] over a period of 12 weeks. Day old guinea fowl keets [n=120] were randomly assigned to four treatment groups, each with 3 replicates. The first treatment was designated as control [T[0]] in which no supplement was added to the feed, while in treatments T[1], T[2] and T[3], NLP was provided as 1, 2 and 3 g per kg of feed, respectively. The results revealed a significant increase in body weight at 12 weeks; 1229.7 for T[1], 1249.8 for T[2], and 1266.2 g T[3] compared to 1220.0 g for the control group [P<0.05]. The results also showed that the supplementation of NLP significantly increased feed intake [P
Subject(s)
Animals , Azadirachta , Plant Leaves , Growth Substances , PowdersABSTRACT
Chyluria can be confused with nephrotic syndrome when massive proteinuria is present on urine examination during evaluation of a milky/white urine. Our objective was to attempt to resolve diagnosis in the case of nephrotic range proteinuria when there is no clear evidence of a significant kidney lesion. Retrospective review of the medical records of all patients referred the nephrology department at a single institution. We identified a subgroup of patients misdiagnosed with nephrotic syndrome and treated aggressively with immunosupression with no benefit and who were later diagnosed as having chyluria. Twelve patients were identified [8 men, 4 women] with a median age of 34.5 years. Chyle was positive in the urine in eight while chyle was positive on oral ingestion of butterfat in another 4. Six had undergone kidney biopsy and were treated as having minimal change disease. Eight had massive proteinuria and a history of treatment with prednisone, but none of these patients had shown improvement in their clinical presentation. Two patients showed excellent results with diethylcarbamazine with angiotensin-converting enzyme inhibitors in while eight required betadine instillation in the fistulous connection with success in six. Surgical correction was successfully tried in two of these resistant cases. In individuals with nephrotic range proteinuria with a normal or low lipid profile status along with normal serum albumin levels, urine color and nature, frequency, and checking the urine for chyle can help identify the large subgroup who unnecessarily have to undergo kidney biopsy and at times are treated with immunosuppression, which is not only life threatening but useless in these patients.
ABSTRACT
To compare the pharmacokinetics and tolerability of two preparations of cyclosporine. The bioavailability of two preparations of cyclosporine [Panimun Bioral, Panacea Biotec India and Sandimmun Neoral, Novartis Switzerland] was compared in 10 adult patients of ESRD on maintainence haemodialysis by enzyme multiplied immunoassay technique [EMIT] after 6.5 days of cyclosporine [5 mg/kg body weight/day in two divided doses] of either brand, with a clearance period of one week in between the two. Area under the curve [AUC], maximum whole blood concentration [Cmax], time to achieve Cmax [Tmax], half life [T1/2], constant of elimination [Kel] was calculated by computer software programme [PK Solutions]. The relative bioavialability of Panimun Bioral was 93%. The AUC [0-12] hours. Cmax Tmax, T1/2 and Kel was not statistically significantly different and side effects with both were minimal. The two preparation were bioequivalent